Renal insufficiency can present systemic symptoms, such as water, electrolyte metabolism disorders such as edema, gastrointestinal symptoms such as nausea, vomiting, cardiovascular symptoms such as heart failure, respiratory symptoms such as pulmonary edema, and so on. 1. Water and electrolyte metabolism disorders: metabolic acidosis and water and sodium balance disorders are the most common, which can be manifested as lack of appetite, deep and long respiration, and peripheral edema. 2. Gastrointestinal system: digestive system is often the earliest manifestation of chronic renal insufficiency, including lack of appetite, nausea, vomiting. Gastrointestinal bleeding is also more common, mostly due to gastric mucosal erosion. 3. Cardiovascular system: Most patients have different degrees of hypertension, causing atherosclerosis and left ventricular hypertrophy. With the continuous deterioration of renal function, heart failure, atherosclerosis and other diseases appear. 4. Respiratory system: patients present with excessive body fluid and cardiac insufficiency, which can cause pulmonary edema and pleural effusion. In addition, the increased permeability of alveolar capillaries can cause uremic pulmonary edema. There are many other symptoms of renal insufficiency, it is recommended that patients go to regular hospitals in time, under the guidance of the doctor for standardized treatment, so as not to delay the condition.