If the patient has a slightly puffy upper eyelid, the specific causes are as follows: firstly, it should be considered whether there is an endocrine metabolic disease, for example, when the patient has a history of thyroid insufficiency, it is necessary to consider the hypothyroidism and adrenocortical insufficiency, and there will be a puffy upper eyelid accompanied by puffiness all around the face. Secondly, in the case of chronic renal insufficiency, the patient will have a large amount of proteinuria, hypoproteinemia, and puffiness occurs in the eyelids and facial tissues. Then, for patients with chronic poor nutritional status, such as anemia and other factors or insufficient food intake, patients may also experience swelling of the upper eyelids and eyelids of the face due to hypoproteinemia. Finally, patients with chronic heart failure may also experience swelling of the upper eyelids.