Bone puncture (myelocentesis) can be painful, but the pain is generally mild and can be tolerated by most patients. Bone marrow aspiration is one of the most common clinical tests used in medicine, where a small amount of bone marrow is extracted for cytologic examination. Bone marrow aspiration can be used to diagnose blood disorders such as leukemia, thrombocytopenic purpura, multiple myeloma, and myelodysplastic syndromes. It can also diagnose parasitic diseases, such as black fever caused by parasites. Bone marrow aspiration is usually done by taking the anterior superior iliac spine and posterior superior iliac spine after local anesthesia and may be mildly painful. However, different people have different levels of sensitivity to pain as well as tolerance, and the pain may vary, but most patients can tolerate it. It is important to note that infection needs to be prevented after a bone marrow aspiration and bathing should not be done for 2 to 3 days. If the patient is unable to tolerate the pain after bone marrow aspiration, he/she can take pain medication to relieve the pain under the guidance of the doctor, such as celecoxib capsules.