High blood creatinine alone has clinical significance. The significance of high blood creatinine has glomerular filtration function hypoperfusion, physiological changes and so on. 1. Glomerular filtration hypoperfusion: high serum creatinine should first be considered as glomerular filtration hypoperfusion, especially in patients with acute renal failure and chronic renal failure. 2. Physiological changes: normal elderly or emaciated blood creatinine is generally low; muscular athletes, strenuous exercise, certain drugs (metformin) and other conditions, there can be a simple high blood creatinine level, at this time there is generally no need for special treatment, regular review can be. If the creatinine level is high, it is recommended to go to the hospital in time to check the specific cause and treatment, so as not to delay the condition.