The transparent hard granules on the hands are considered to be the appearance of sweat herpes, tinea cruris, infectious molluscum contagiosum, eczema and other diseases, which can be treated with general treatment, medication, physical therapy and so on. 1. Sweat herpes, after the appearance of sweat herpes, due to changes in skin tissue, metabolic ability to slow down, sweat may appear after the collection of transparent hard granular material, you can use tacrolimus, pimecrolimus and other drugs under the guidance of the doctor treatment. 2. ringworm, clinical ringworm after the skin tissue by fungal infection may lead to blisters, you can use fluconazole, itraconazole and other drugs under the guidance of the doctor treatment. 3. Molluscum contagiosum, patients with molluscum contagiosum may also lead to the hands of long transparent hard particles, generally can be laser treatment or surgical treatment. 4. eczema, patients with eczema skin sensitivity increased, may appear this symptom, can be under the guidance of the doctor to use loratadine, cetirizine and other drugs treatment. Clear hard particles on the hands may also be caused by other reasons, it is recommended to consult a doctor in a timely manner, after clarifying the cause of the disease under the guidance of the doctor for treatment, do not self-medication.