Two shots of vaccine not from the same manufacturer is not necessarily okay. You need to meet the same vaccine type and dosage form at the same time before you can consider vaccination, otherwise you cannot be vaccinated. Common vaccines mainly include inactivated vaccines and live attenuated vaccines. Inactivated vaccine is a vaccine made by artificial chemical or physical inactivation of pathogenic microorganisms, which can stimulate the body to produce specific antibodies or sensitized T lymphocytes to generate the corresponding immune response and exert immune effects. Live attenuated vaccines, on the other hand, are made by artificial special treatment of pathogens to make them lose their pathogenicity but still retain their immunogenicity, and generally only one vaccination is needed, and the dosage is small, but the validity period is relatively short and there is a certain risk of virulence reversion. In addition, there are new types such as mRNA vaccines, in which the pathogenic microorganism RNA is modified in vitro and then delivered to the body for intracellular expression, so that the body produces protein antigens and immune responses to enhance the body’s immunity to such pathogenic microorganisms. Therefore, there is no significant difference in the principle of action between vaccines of the same type from different manufacturers, so it is theoretically possible to administer two doses of vaccines from different manufacturers. In case of special circumstances such as unavailability of some vaccines or change of vaccination sites, when vaccination cannot be completed with vaccines made by the same manufacturer, vaccine products made by other manufacturers of the same type and dosage form can be used to complete the entire vaccination. For two doses of vaccine, you should try to choose the vaccine made by the same manufacturer, and you should consult with the vaccination unit before vaccination to determine whether it is possible to mix the vaccines to avoid affecting the effect of the vaccine.