Women will have some abnormal manifestations before menopause: firstly, it may be the change of menstruation, the change of menstrual cycle is the earliest clinical symptom appearing, which can be roughly classified into three types: 1, prolongation of menstrual cycle, reduction of menstrual flow, and finally menopause; 2, irregular menstrual cycle, prolongation of menstruation, increase of menstruation flow, or even profuse bleeding or bleeding drenching, and then gradually reduce and stop; 3, it is less common is the menstrual Sudden cessation of menstruation. Secondly, there are symptoms of vasodilatation, mainly manifested as hot flashes and sweating. Third, there can be mental and neurological symptoms, mainly including mood, memory and cognitive symptoms. Fourth, there can be symptoms of the genitourinary tract.