1.Adolescents who are physically fit, children. 2.Acute diseases and those with infections. 3, chronic disease attack and active period. 4.People with stomach pain, diarrhea, cholecystitis, gallstone attack. 5, chronic hepatitis, transaminases are very high. 6, pregnancy. It is better to have a physical examination before taking the cream; those who have more than double the serious excess of blood lipids; those who have abnormal liver function during the active period of liver disease; those who have not operated on tumor lesions and patients with acute infectious diseases such as cold and fever are not suitable for taking the cream.