Multi-organ dysfunction, often encountered in critical care, is related to the following reasons: 1, large trauma, including burns, multiple injuries, major surgery, these are large stress conditions for the body, where blood and fluid loss may lead to multi-organ dysfunction; 2, heavy infections: including sepsis, abdominal infection like pancreatitis, strangulated intestinal necrosis, these may cause multi-organ dysfunction; 3, major surgical operations including craniocerebral surgery, open-heart surgery, may induce multi-organ dysfunction; 4, sometimes blood transfusion, including some drugs, if related complications occur in the process, can also appear multi-organ dysfunction; 5, various causes of shock, including infectious shock, hemorrhagic shock, can lead to; 6, cardiac arrest after resuscitation, there is a delay in resuscitation or incomplete resuscitation, may be secondary to various organ dysfunction ; 7, some patients also have susceptibility factors, such as the elderly some organ function itself is poor patients, plus there are immunocompromised patients. These are all triggers for multi-organ failure.