Is it dangerous to have high cerebrospinal fluid protein? High cerebrospinal fluid protein is dangerous because it can cause adhesions in the arachnoid membrane, which can affect the circulatory pathways of the cerebrospinal fluid and lead to obstruction of the cerebrospinal fluid. High cerebrospinal fluid protein is usually seen in patients with severe intracranial infections, or in patients with Guillain-Barre syndrome, who have very high protein for about two weeks. Some patients with spinal cord inflammation may also have a particularly high protein level in the cerebrospinal fluid, which can easily cause obstructive hydrocephalus, resulting in life-threatening conditions, so a high protein level in the cerebrospinal fluid is very dangerous.