Children’s sinusitis can be divided into acute and chronic sinusitis, pediatric acute sinusitis commonly used drugs include antibiotics such as amoxicillin clavulanate potassium and anti-allergy drugs such as chlortetracycline syrup, cetirizine drops and reduce nasal mucosal congestion agent such as hydroxymethazoline hydrochloride nasal drops and other medications, all have certain side effects, there is no which drug side effects are minimized, it is recommended to follow the doctor’s instructions for use of the drug. Amoxicillin Clavulanate Potassium adverse reactions involve various systems, including rash, itching, nausea, vomiting, diarrhea, arthralgia, dizziness, leukopenia and thrombocytopenia, hematuria, elevated aminotransferases, palpitations, dyspnea, chest tightness, and chills. Common adverse reactions to loratadine syrup include malaise, headache, drowsiness, dry mouth, nausea, and rash. Rare adverse reactions include alopecia, allergic reactions, abnormal liver function, tachycardia and palpitations. Cetirizine Drops with the recommended dose of cetirizine has mild central nervous system side effects, including drowsiness, fatigue, dizziness, and headache. In some cases, central nervous system excitation has also been reported. Adverse reactions such as diarrhea, vertigo, and rash may also occur. Hydroxymetazoline hydrochloride is contraindicated in children 2 years of age and younger. Too frequent use of the drops is likely to result in rebound nasal congestion, and prolonged use may result in drug-induced rhinitis. A small number of people have a slight burning sensation, pins and needles, nasal mucosa dryness, as well as headache, dizziness, rapid heart rate and other reactions. Allergic reactions are rare. Drugs have certain side effects, need to be used at the discretion of the specialist according to the condition.