Darkening around the lips usually works with hydroquinone cream tube, is somewhat effective. Hydroquinone, the main ingredient in hydroquinone cream, belongs to a kind of skin discoloring agent, which is commonly used in the clinical treatment of chloasma, freckles, inflammation and post-surgical hyperpigmentation spots. Hydroquinone cream can inhibit melanin cell metabolism, so that the skin gradually fades to its original skin color. Most of the darkening around the lips is melanin deposition, so using hydroquinone cream is effective. However, it should be noted that when using hydroquinone cream, adverse reactions such as burning sensation and allergic reaction may occur. At the same time, the drug should be used only on the lesions, do not apply it to normal skin. If the cream appears discolored, its use is prohibited. Hydroquinone is prohibited for those who are allergic to it, as well as for pregnant women with children under 12 years of age. Hydroquinone cream is a prescription drug and should be used under the supervision of a doctor to avoid self-medication.