Side effects of trastuzumab include nausea and vomiting, cough, anemia, and alopecia, while side effects of patuximab include fatigue, weakness, and peripheral edema. 1. Trastuzumab: common adverse effects include nausea and vomiting, diarrhea, constipation, decreased appetite, cough, anemia, leukopenia, neutropenia, thrombocytopenia, alopecia, and fatigue. 2. Pertuzumab: common adverse reactions include fatigue, mucosal inflammation, weakness, peripheral edema, fever, alopecia, rash, nail disease, diarrhea, nausea, stomatitis, anemia, peripheral neuropathy, myalgia, loss of appetite, headache, constipation, leukopenia, and so on, and in serious cases, there are left ventricular dysfunction, embryo fetotoxicity, infusion-related reactions, allergic reactions. It is recommended that patients who are unwell go to regular hospitals in time, and follow the doctor’s instructions for symptomatic treatment with medication.