Blisters on the hands after taking Gui Fu Di Huang Wan is not normal, it may be caused by allergy to the ingredients of Gui Fu Di Huang Wan, it is recommended to stop taking the medicine immediately and consult a professional Chinese medicine practitioner for treatment. Gui Fu Di Huang Wan is composed of cinnamon, epimedium, ripened rhizome, cornelian cherry and peony bark. It has the effect of warming and tonifying kidney yang (warming and replenishing kidney yang). It is used for deficiency of kidney yang (lack of yang qi in the kidneys), soreness and coldness of the waist and knees, dysuria (unsmooth urination) or regurgitation of excessive urination, and phlegm (pathological product formed by impaired metabolism of water and fluids) wheezing and coughing. It should be noted that, avoid indigestible food; cold and fever patients should not take; during the treatment period, it is advisable to abstain from sexual intercourse; yin deficiency and internal heat is not applicable; this drug should be taken before meals or at the same time as eating; after taking the drug for 2 weeks without improvement in symptoms, or the appearance of symptoms such as loss of appetite, headache, gastric discomfort, etc., it should be to the hospital for consultation. If you need to take medication, you should be under the guidance of a doctor for scientific treatment.