Glimepiride tablets and Dagliflozin can be taken at the same time, need to strictly follow the doctor’s instructions. Glimepiride belongs to the sulfonylurea hypoglycemic drugs, mainly through the stimulation of pancreatic islet B cells to release insulin, so as to reduce blood glucose concentration. It can be used to treat type 2 diabetes where exercise therapy, dietary control, and weight loss cannot control blood sugar well. it is contraindicated in patients with type 1 diabetes, hepatic and renal insufficiency, etc. Hypoglycemia may occur after taking the drug, and the drug should be stopped immediately. Dagliflozin belongs to the sodium-glucose co-transporter protein 2 inhibitor, by reducing the reabsorption of glucose filtered through the renal tubules, so that it is excreted from the urine, and then achieve hypoglycemic effect. Side effects such as genitourinary infections may occur and are contraindicated in patients with severe infections, renal insufficiency, and diabetic ketoacidosis. Glimepiride tablets and Dagliflozin can enhance the effect of hypoglycemia when taken together, but attention should be paid to the fact that blood glucose should be monitored regularly, and the dosage should be adjusted if there is a phenomenon of too low blood glucose. If you need to take hypoglycemic drugs, you should go to the hospital in time, follow the doctor’s instructions for medication, do not recommend self-medication.