Menopausal women with thyroid nodules who are deficient in estrogen can usually take reasonable estrogen supplements as prescribed by their doctors. Due to the obvious decrease of estrogen level in the body, menopausal women may have a series of uncomfortable symptoms, such as insomnia, excessive sweating, palpitation, emotional irritability, etc. Appropriate supplementation of estrogen can alleviate the symptoms to a certain extent, so menopausal women can take appropriate supplementation of estrogen. Menopausal women with thyroid nodules combined with hypothyroidism need to pay attention to estrogen supplementation. Taking estrogen will lead to increased levels of thyroid-binding globulin, and patients who rely on thyroxine replacement therapy may need to increase the dose of thyroxine if they are also taking estrogen. Menopausal women with thyroid nodules who need supplemental estrogen therapy should consult a medical professional and follow the doctor’s instructions for standardized medication.