Chronic nephritis for 50 years usually cannot be cured, but it can be slowed down by general treatment, medication and surgery. 1. General treatment: Limit the intake of protein and phosphorus in food, avoid exertion and infection, and use nephrotoxic drugs carefully. 2. Drug therapy: ACEI or ARB drugs such as captopril and irbesartan can be applied to lower blood pressure and reduce urinary protein, and glucocorticoids and cytotoxic drugs such as prednisone and cyclophosphamide can also be applied. Patients with severe edema can relieve symptoms by using diuretics such as hydrochlorothiazide. 3. Surgical treatment: Surgical treatment has the way of kidney transplantation, which is suitable for patients with end-stage chronic kidney disease. All the above medications should be used under doctor’s guidance, avoid self-medication. Patients with chronic nephritis are advised to go to regular hospitals in time and receive standardized treatment under the guidance of doctors.