The key to the treatment of lumbosacral tuberculosis is early detection and early treatment, with drug therapy as the main treatment, supplemented by surgery. 1. Drug therapy: Isoniazid, rifampicin, pyrazinamide (or ethambutol) combination therapy is the first choice of drugs for the treatment of tuberculosis, and the triple combination of drugs can avoid the drug resistance produced by a single drug, so as to improve the clinical efficacy. Because of the poor blood supply in the lumbosacral area, the drug penetration is slow, so it is necessary to take the drug for a long time, and the liver function needs to be checked regularly. 2. Surgery: If the patient has secondary infection of tuberculosis, or if the tuberculosis leads to local deformity, the abscess can be removed or the spinal deformity can be corrected through surgery. Anti-tuberculosis treatment is still needed after surgery. Patients with lumbosacral tuberculosis need to strictly follow the medication cycle, and remember not to stop or reduce the dosage without authorization, so as not to affect the therapeutic effect.