Whether creatinine 260μmol/L affects life expectancy varies from individual to individual, depending on the cause of creatinine elevation. Physiological factors usually do not affect life expectancy, while pathological factors, such as untimely treatment and progression of the disease to renal failure or even uremia, will affect life expectancy. Creatinine is the product of muscle metabolism in the body, of which 44-97 μmol/L for women and 53-106 μmol/L for men. 260 μmol/L creatinine exceeds the upper limit of normal value, which belongs to the creatinine increase. Elevated creatinine caused by physiological factors such as strenuous exercise, excessive consumption of meat, etc. Usually, creatinine can be gradually recovered after eliminating the causative factors, and life expectancy is usually not affected. Pathological factors such as acute kidney injury, through active treatment, such as creatinine decline and return to normal, usually does not affect life expectancy. Kidney injury caused by all types of glomerulonephritis and pyelonephritis, if creatinine decreases or stabilizes at 260 μmol/L after treatment, life expectancy is usually not affected. Regardless of acute or chronic renal failure, if the treatment is not timely, the condition progresses to the renal failure stage of renal uremia, the body develops acidosis, water-salt balance disorders, electrolyte metabolism disorders, etc., which can have an impact on life expectancy. It is recommended that people with abnormal creatinine, go to the hospital in time, improve the relevant examination under the guidance of the doctor, if it is caused by pathological factors should be actively treated to avoid the development of the disease.