Soreness from the knee down to the soles of the feet needs to be treated according to the cause of the problem, generally there are rest, physical therapy, anti-inflammatory and pain-relieving drugs such as Lexapro and surgical treatment. 1. Physiological reasons: such as overwork and muscle spasms and other causes of lactic acid accumulation in the body muscles, the patient may appear below the knee to the soles of the feet feel sore and painful. The main treatment is to rest, hot compresses and other physical therapy to promote the absorption of metabolic products. 2. Trauma: due to trauma and other reasons to the patient’s knee joints, blood vessels and peroneal nerve damage, the patient may appear below the knee to the soles of the feet feel soreness and pain. When the injury is mild, rest, early cold compresses, ibuprofen, celecoxib and other anti-inflammatory pain medications can be given. When the injury is more serious, surgery can be considered. 3. Lumbar disc herniation: Due to the compression of the nerve roots innervating the lower limbs caused by lumbar disc herniation, patients may feel soreness and pain from the knees down to the soles of the feet. Treatment includes bed rest, physical therapy such as electric grilling, anti-inflammatory and pain-relieving drugs such as celecoxib, and conservative treatment, followed by surgery if necessary. 4. Lower extremity vascular diseases: such as lower extremity arterial embolism, lower extremity varicose veins and other diseases can cause soreness and pain from the knee down to the soles of the feet. Treatments such as aspirin and other antiplatelet agents, rivaroxaban and other anticoagulant agents, and surgery will be given. It is recommended to consult a doctor to identify the cause of the pain and to treat it with the help of a doctor. The above drugs need to be used under the guidance of a doctor to avoid self-medication.