Sildenafil and Dapoxetine are generally not recommended for use together, but can be taken together if the patient has both impotence and premature ejaculation. Sildenafil is used for the treatment of erectile dysfunction; adverse reactions include vomiting, allergic reaction, shock, fatigue, angina pectoris, atrioventricular block, syncope, tachycardia, palpitations, hypotension, myocardial ischemia, heart failure, dyspnea, etc.; Dapoxetine is used for the treatment of premature ejaculation in male patients aged 18-64 years old, and the adverse reactions include headache, nausea and vomiting. Sildenafil and Dapoxetine both have significant gastrointestinal and cardiovascular side effects, and taking them at the same time may lead to side effects superimposed on each other. It is recommended that the doctor choose one of the drugs for treatment according to the patient’s specific situation. If the patient has both impotence and premature ejaculation, and there is no other contraindication, you can consider taking them together. Before use, it should be noted that sildenafil is forbidden to be combined with nitrate drugs, and this drug is forbidden for women, people who are allergic to this product, children, and people whose recent cardiovascular status makes them unfit for sexual life. Dapoxetine hydrochloride is contraindicated in people who are allergic to this product, in patients with a significant pathological condition of the heart, in patients with moderate and severe liver damage. The drug can also not be used in conjunction with thioridazine, strong cytochrome P450 3A4 inhibitors, monoamine oxidase inhibitors. It is recommended that patients usually eat more fresh vegetables and fruits, strengthen exercise, do not stay up late, adjust the mentality, moderate the frequency of coitus, if necessary, can go to the hospital, follow the doctor’s instructions for treatment.