The possible causes of lymph node enlargement without pain or itchiness include: lymph node tuberculosis, nodal disease, lymphoma, metastasis of malignant tumors, etc. The treatment modalities are different, including anti-tuberculosis treatment, surgical resection, chemotherapy, and targeted therapy. 1. Lymph node tuberculosis: Lymph node tuberculosis should be treated with strict and regular anti-tuberculosis treatment firstly, and commonly used drugs include isoniazid, rifampicin, streptomycin, etc. A few large and confined lymph nodes should be treated with anti-tuberculosis treatment. Surgical resection can also be considered for a few larger limited lymph nodes. 2. Nodal disease: the treatment of nodal disease should be decided according to the condition, asymptomatic or stable stage I, II, III nodal disease can not be treated with special treatment, and regular follow-up can be enough. If there are obvious intra- and extra-pulmonary symptoms, long-term glucocorticoid maintenance treatment is needed, and the general course of treatment is 6~24 months, and regular review is needed until the condition is stabilized after the end of treatment. 3. Lymphoma: Lymphoma is mainly treated with chemotherapy, commonly used drugs include vincristine, prednisone, doxorubicin, etc. The specific chemotherapy program and cycle of chemotherapy should be decided according to the pathological type and clinical staging. Chemotherapy combined with radiotherapy can effectively reduce the risk of recurrence and improve the survival rate. For patients with stable condition and eligible patients, high-dose chemotherapy can be combined with hematopoietic stem cell transplantation. 4. Metastasis of malignant tumors: Thyroid cancer, breast cancer and other malignant tumors are prone to lymph node metastasis, according to the condition, patients can choose radical surgery combined with lymph node dissection, chemotherapy, radiotherapy, targeted therapy, immunotherapy and other treatment modalities. It is recommended that patients with painless enlarged lymph nodes should go to the hospital as soon as possible to get a clear picture of the nature of the lymph nodes and be treated under the guidance of professional doctors.