The time of effect of Secret Clearing San is related to the severity of the disease and the sensitivity of the individual to the drug, and the exact time varies from person to person. Secret Qingliang San has the effect of clearing heat and detoxifying, cooling blood heat and resolving phlegm and dampness. It can be clinically applied to viral hepatitis, alcoholic cirrhosis, hepatomegaly, jaundice and pain in the liver area caused by liver cancer, with detoxification, extirpation of toxins and diuresis. However, the effect time after the use of Secret Qingliang San is related to the individual patient’s condition. For mild patients its effect time may be faster, and the patient’s symptoms such as abdominal distension, liver pain, poor appetite and weakness will be gradually relieved. However, for severe patients, such as those with cirrhosis of the liver and advanced hepatocellular carcinoma, their symptoms are more severe, so the effect time after taking Secret Qingliang San may be a little later. In conclusion, for the use of proprietary Chinese medicine, patients need to receive guidance from clinicians for evidence-based treatment, and should pay attention to rest and avoid strain and spicy and stimulating foods.