There is no contraindication to the pairing of Nephrolithone Granules and Prostatol Soft Capsules, but both drugs contain hyssop, and taking them at the same time may have the risk of drug overdose, it is not recommended to take them at the same time, and you need to use them under the guidance of a doctor. Nephrolithone Granules is a medicinal product, which consists of Qiancheng, Wangbuliuhang, Polygonum aviculare, Yanhuisuo, Jinnaijin, Salvia miltiorrhiza, Mucuna pruriens, Qu Mai, Cowslip, Hai Jinsha, which has the effect of clearing away heat and removing dampness (removing heat and dampness in the body), invigorating blood circulation and relieving pain (alleviating pain by eliminating stagnant blood circulation), dissolving stones, and discharging stones. Nephrolithone Granules are used for the treatment of kidney stones, renal pelvis stones, bladder stones and ureteral stones. The adverse effects and contraindications of the drug are not clear. Avoid taking spicy and stimulating food during the period of taking the medicine. Prostate Shule Soft Capsule is a Chinese patent medicine, composed of Epimedium, Astragalus, Pseudostellariae, Plantago Ovatae, Sichuan hyssop, with the effect of tonifying the kidney and benefiting the vital energy, resolving blood stasis and clearing the flow of gonorrhea. Prostate Shule Soft Capsule is used for the treatment of double deficiency of kidney and spleen, stagnation of qi and blood stasis (blood stasis due to lack of qi circulation), prostate hyperplasia, chronic prostatitis, pallor (white color and lack of luster), fatigue (mental exhaustion and physical weakness), weakness and weakness of the waist and knees, abdominal distension, dysuria, dribbling, or frequent urination, urinary urgency, and astringency of the urethra. The adverse reactions and contraindications of the drug are not clear. Kidney Stone Pellets and Prostate Shule Soft Capsules both contain hyssop, and are not recommended to be taken at the same time, and need to be used under the guidance of a doctor, not self-medication.