Squatting knee pain may have the following causes: first, patellofemoral arthritis, if squatting when patellofemoral arthritis occurs, it can occur between the patella and femur joint surface, cartilage friction, serious resulting in knee pain, then to carry out related knee X-ray, nuclear magnetic examination for early diagnosis and treatment. Second, meniscal injury, when there is a tear in the posterior horn of the meniscus, there can be pain at the back of the knee when squatting, then the relevant examination and MRI of the meniscus should be carried out for early diagnosis and treatment. Thirdly, synovitis, when there is synovitis, there can also be pain in the knee when squatting, which is due to the irritation and compression of the synovial membrane when squatting, and it is important to have a physical examination and MRI of the knee for diagnosis and treatment.