Edema of the eyelid after taking Imatinib belongs to the adverse drug reaction. Imatinib is an antitumor drug, mainly used for the treatment of leukemia, gastrointestinal mesenchymal stromal tumors and other diseases, there may be eyelid edema and other side effects after the use of the drug, if the degree of eyelid edema is not serious, it does not affect the use of the general. However, if eyelid edema affects normal life, or even causes mechanical ptosis, or even causes blurred vision, the dosage can be reduced or even discontinued according to the doctor’s instructions, and after discontinuation of the drug, the eyelid edema may gradually disappear through the metabolism of the drug. If the patient’s eyelid edema is not relieved for a long time, ophthalmology specialist consultation is recommended, and other diseases can be considered, such as low albumin, renal insufficiency, etc., which need to be clearly diagnosed and targeted treatment. It is recommended that patients who develop severe eyelid edema after using imatinib should consult an ophthalmologist promptly to evaluate their condition and follow the doctor’s instructions for treatment.