The mode of inheritance of genetic disorders refers to the characteristics of the genetic information transmitted in genetic disorders and can be divided into single-gene mode of inheritance and polygenic mode of inheritance. Single-gene inheritance is more common, and it can be divided into autosomal and sex chromosomal inheritance. Autosomal inheritance generally conforms to Mendel’s law of inheritance, and there are also mitochondrial genes associated with mitochondria, which is a matrilineal mode of inheritance. Polygenic genetic disorders are generally associated with the deletion or mutation of multiple genes, mainly related to the birth of close relatives, and can be relatively harmful to people, such as some psychoneurological disorders, as well as cleft lip, cleft palate, and multiple malformations. There is also a chromosomal disorder caused by consanguineous marriage, which is also a type of genetic disorder.