It is important to know that the skull is a very important bone in our head, which is the barrier between our brain and the outside world and protects the normal operation of the tissues in the brain. The skull may be defective for many reasons, due to accidentally being hit by something that can easily cause damage to the brain, or due to a lesion in the skull itself that requires debridement surgery, thus causing a defect in the skull. Generally, if the defect area exceeds 3cm*3cm or more, skull repair is necessary. If you don’t go to the hospital for repair in time, it will be very harmful and can’t make the brain tissue get a good protection, which will affect the normal operation of human body, and it will make the patient have a great psychological obstacle in the long run, because the brain collapse or expansion feel different from the normal people, produce inferiority complex, not confident, which will affect the patient’s life and work to a great extent. Therefore, patients with large skull defects should undergo skull repair surgery as soon as possible within three months after surgery. Some repair materials can also cause side effects after the repair. The most widely used titanium mesh can cause rejection or other side effects in some patients after using it, so patients should also choose the repair hospital and materials carefully. Currently, some hospitals are using a new type of material for patients to perform cranial repair, polyether ether ketone material, commonly known as peek material is the most ideal repair material recognized by many experts at present.