A low albumin-to-globulin ratio suggests that the patient may have problems with liver function, but other factors such as kidney function or malnutrition may also have some effect on the albumin-to-globulin ratio. The normal ratio of albumin to globulin in clinical liver function tests is (1.5-2.5):1, with more albumin than globulin. A lower albumin-to-globulin ratio can occur when pathological factors cause low albumin or elevated globulin. Usually viral, drug or alcoholic hepatitis can cause damage to the patient’s liver function, resulting in a decrease in albumin, while immune diseases or diseases of the kidneys and other organs can lead to a loss of albumin and an increase in globulin values. Therefore, the specific cause of an altered albumin to globulin ratio needs to be detected by specific tests and treated effectively. If it is a liver lesion, treatment should be directed at the cause of liver disease. Patients can protect their liver and liver by taking measures such as anti-viral, quitting alcohol and stopping drug damage, so that the albumin ratio can return to normal.