Whether treatment is necessary for a 70-year-old patient with chronic lymphocytic leukemia for more than 10 years is determined by the specific condition. Chronic lymphocytic leukemia is a malignant disease of the blood system that is difficult to cure completely, but some patients can be left untreated in the early stages of the disease, and the disease progresses slowly. When patients with chronic lymphocytic leukemia have therapeutic indications, they need to be treated, and they can choose targeted drug therapy or combined chemotherapy. 1. If the patient has progressive worsening of anemia and/or thrombocytopenia, progressive enlargement of the spleen, progressive enlargement of the lymph nodes or lymph nodes with a diameter greater than 10 cm, significant increase in the lymphocyte count, and symptoms (weight loss, significant fatigue, night sweats, etc.), then treatment is needed in a timely manner. Therapeutic drugs include nitrogen mustard phenylbutyrate, ibrutinib and so on. 2. If there are only elevated lymphocytes without the above indications for treatment, the patient can be left untreated for the time being, and regular monitoring is sufficient. It is recommended that the patient go to the Department of Hematology, where the specialist will evaluate the condition and decide whether to start treatment and formulate an individualized treatment plan.