There is no such thing as 4 early manifestations of hypothyroidism. Hypothyroidism progresses slowly, and can be asymptomatic in the early stages, or manifest as non-specific symptoms such as fatigue and drowsiness. The onset of hypothyroidism is insidious, the course of the disease is long, the disease can be asymptomatic in the early stage, can also be manifested as fatigue, drowsiness and other non-specific symptoms, with the progress of the disease gradually appeared slow reaction, hair loss, hoarse voice, loss of appetite, joint swelling and pain, weight gain, menstrual disorders, memory loss, and mucus oedema and other manifestations. Treatment for hypothyroidism is mainly replacement therapy with levothyroxine sodium tablets. When patients suspect hypothyroidism, they should go to the hospital for examination and clear diagnosis.