Itchy blisters on the soles of the feet may be caused by tinea pedis, eczema or palmoplantar pustulosis. 1. Tinea pedis: often occurs in the summer, is a common superficial fungal disease, such as blisters, can occur in between the toes, foot metatarsal or foot side edge, etc., lesions can be the initial pinpoint-sized blisters, the blister wall is thicker is not easy to rupture, if the fusion into a multi-compartmental blisters, in the tear off the wall of the blisters can be a bright red vesicular surface, drying with the flaking, often accompanied by obvious itching. 2. eczema: can occur in the feet, hands, calves and other parts of the skin lesions can be manifested as corn grain size papules, papules, serious cases can be small blisters, with intense itching, scratching can be formed vesicles. 3. palmoplantar pustulosis: pustular psoriasis, foot and metatarsal can occur in the middle of the toes as well as the inner side, lesions manifested as erythema on the basis of small pustules, itching and burning pain, in 1 ~ 2 weeks after the pustules can be ruptured, crust, and then there is a new pustule, after a long time. When the soles of the feet long blisters, it is recommended to consult a doctor in a timely manner to clarify the cause of the blisters, and then follow the doctor’s instructions for treatment.