If the patient frequently breathes with the mouth open while sleeping, it is often due to inflammation in the patient’s nasal cavity or nasopharynx, sometimes caused by a deviated septum or polyps in the nasal cavity or new organisms in the nasopharynx. Patients are advised to visit the hospital promptly for a clear diagnosis. If it is because of inflammation, it is recommended that the patient actively take oral cefdinir dispersible tablets to reduce inflammation, and at the same time, local spray can be improved with mometasone furoate nasal spray. If it is determined that there is neoplastic formation or deviated nasal septum, surgery can be considered. When the patency of the nasal cavity and nasopharynx improves significantly, the patient does not need to open his mouth to breathe when he sleeps, which can effectively improve his sleep quality. It is recommended that the patient sleeps in a lateral position to effectively avoid the backward fall of the tongue.