The sonographic changes of chronic liver disease vary with the severity of inflammation in the liver and the severity of fibrosis, and there are differences in the performance of mild and severe patients. 1. Mild patients: in mild cases, the sonogram shows thickening and enhancement of liver parenchymal echoes with uneven distribution, the size of the liver often has no obvious clinical manifestations, and the spleen may be normal or slightly enlarged. 2. Severe patients: patients with severe hepatitis or cirrhosis can show that the surface of the liver is not smooth, the liver parenchyma is small nodules, uneven distribution, liver inflammation and fibrosis are obvious, hepatic vein and hepatic portal vein branches become thin, intrahepatic blood vessels are not clear, the wall of the gallbladder is thickened, and the spleen can have the problem of enlargement. When liver lesions are detected, they need to be judged in combination with the patient’s clinical symptoms and relevant auxiliary examinations.