Temporomandibular arthritis is an aseptic inflammatory disease, mostly caused by chronic injury from chewing harder foods or prolonged chewing movements. In the field of pain, whether it is caused by knee arthritis or shoulder arthritis, intra-articular ozone injection for arthritis is a new treatment method that has emerged in recent years. The mechanism of action is to take advantage of the strong oxidative properties of ozone, 1) ozone stimulates oxidase overexpression, neutralizes reactive oxidation products, antagonizes cytokines, causes vasodilation, and promotes inflammation absorption; 2) ozone acts on the nerve endings around the joint Ozone can stimulate the release of enkephalins from inhibitory interneurons to achieve analgesic effects; 3) ozone can change the intra-articular environment, promote cartilage repair and regeneration, and prevent or delay degenerative joint changes. Therefore, ozone injection into the joint cavity can eliminate intra-articular inflammation and promote tissue repair. The clinical efficacy is satisfactory, with few complications and minimal symptoms. Supratrochlear TMJ puncture is safe and simple. The subject group was treated with intra-articular ozone injection into the superior temporomandibular joint and the control group was treated with intra-articular tretinoin injection into the superior temporomandibular joint. In terms of postoperative complications, the number of various types of complications in the control group was 3, which reached 10% of the total number of cases in the control group, the same as the treatment group. The post-treatment dizziness and syncope of patients in the treatment and control groups may be related to psychological tension and painful stimulation; facial hematoma and external auditory canal penetration were related to deviations in the process of joint cavity puncture. Complications were rare and mild. No special treatment is needed, and they can all resolve or recover on their own. There are many ways to treat TMJ, such as infrared, laser, and ultrasound physiotherapy. The results of our study prove that intracavitary ozone injection for TMJ is a simple, safe and effective treatment method with low treatment cost, and has the advantages of repeatable treatment and few complications, which can be further promoted in clinical practice.