The chemotherapy regimens for gastric low-differentiated cancer include epirubicin+cisplatin+fluorouracil, oxaliplatin+capecitabine and single-agent fluorouracil regimen, etc. According to the patient’s condition and his/her own situation, the treatment should be carried out under the guidance of professional doctors. If the cancer is progressed low-differentiated gastric cancer or has lymph node metastasis, 3 cycles of epirubicin, cisplatin and fluorouracil chemotherapy can be carried out, and according to the evaluation result of the efficacy of the treatment, surgery or continue chemotherapy can be chosen. If the postoperative pathological stage of gastric poorly differentiated cancer is stage IB or II or above, postoperative adjuvant chemotherapy can be carried out, repeating 6-8 cycles of oxaliplatin combined with capecitabine chemotherapy; single-agent fluorouracil treatment can also be carried out, and the duration of the treatment should not be more than 1 year. In case of advanced gastric low-differentiated cancer, oxaliplatin, calcium folinate and fluorouracil can be chosen according to the patient’s physical condition, and targeted and immunotherapy can also be combined if necessary. There are many chemotherapy programs for gastric poorly differentiated cancer, patients should seek medical treatment in time, choose the appropriate treatment plan under the guidance of the doctor, all the drugs should be applied under the guidance of the doctor, and keep optimistic mindset and strengthen the nutrition during the chemotherapy period.