Tobramycin and ofloxacin eye drops are different in the mechanism of action, antibacterial range, adverse reactions, contraindications and other aspects: 1. Different mechanism of action: tobramycin belongs to aminoglycoside antimicrobials, which plays an antibacterial role by inhibiting protein synthesis; ofloxacin belongs to quinolone antimicrobials, which plays an antibacterial role by inhibiting bacterial DNA synthesis and replication. 2. Different antibacterial scope: Tobramycin has good antibacterial effect on staphylococci and aerobic gram-negative bacilli, such as Escherichia coli, aerobacteria, Klebsiella, Streptococcus, etc. Ofloxacin has strong antibacterial effect on gram-negative and positive bacilli, such as staphylococci, Streptococcus pyogenes, Streptococcus haemolyticus, enterococci and pneumococci. 3. Different adverse reactions: Tobramycin can lead to eyelid redness and itching, edema and congestion, keratitis and corneal abrasion, blurred vision, etc.; Ofloxacin can lead to eyelid itching, ocular burning, discomfort, photophobia, edema, dryness and other adverse reactions. 4. Different contraindications: tobramycin is prohibited for those who are allergic to tobramycin and aminoglycoside antimicrobials; ofloxacin is prohibited for those who are allergic to ofloxacin and quinolone antimicrobials. If there is a need to take drugs, please follow the doctor’s instructions to choose the right drug.