Adults diarrhea for five days without improvement may be caused by inflammatory bowel disease, acute gastroenteritis or irritable bowel syndrome and other diseases, diarrhea for five days without improvement should be promptly to the hospital for examination, according to the cause of the choice of general treatment, drug therapy or surgical treatment. 1. Inflammatory bowel disease: Inflammatory bowel disease is caused by immune, genetic and other factors, the intestinal absorption ability decreases, inflammation stimulates the secretion of mucus and so on, which in turn causes diarrhea. You can take drugs such as Liuzosulfapyridine and Mesalazine under doctor’s guidance. Ineffective medication or recurrence of the author can be evaluated and then surgical treatment. 2. Acute gastroenteritis: Bacterial or viral infections due to unclean food, lowered immunity, etc. can lead to acute gastroenteritis, which may manifest as abdominal pain and diarrhea. Bacterial infections can be treated with drugs such as norfloxacin under the guidance of a doctor, and general symptomatic treatment, such as rehydration, is needed. 3. Irritable Bowel Syndrome (IBS): Chronic mental overstress, anxiety and other factors may trigger IBS, which in turn causes diarrhea. You should pay attention to rest and relax. At the same time, symptomatic treatment, can be taken under the guidance of the doctor pivoxyl bromide for antispasmodic pain, bifidobacteria to regulate intestinal homeostasis and other treatments. When diarrhea symptoms do not improve for five days, need to follow the doctor’s instructions to apply antidiarrheal drugs such as montelukast, etc., at the same time, oral rehydration salts and other treatments to prevent electrolyte metabolic disorders. Gastric mesothelioma and other factors may also cause diarrhea for five days without improvement, should consult a doctor in time to identify the cause, cooperate with the doctor’s treatment, do not self-medication.