How to apply gastrointestinal nutrition in patients with cardiac cachexia syndrome?

  Syndrome of cardiac cachexia (SOCC) is a systemic manifestation of heart valve disease that has progressed to a severe degree and is characterized by cardiac insufficiency, along with endocrine, metabolic, nutritional, and coagulation disorders. Enteral nutrition (EN) is a method of providing nutrients required to maintain normal body metabolism via the mouth or feeding tube. Compared with parenteral nutrition, the advantages of enteral nutrition include more physiological absorption and utilization of nutrients, easier and cheaper administration, and help to maintain the integrity of intestinal mucosal structure and barrier function. For this reason, it has become the consensus of clinicians to use enteral nutrition as long as the gastrointestinal tract is functional.  The clinical recognition of Syndrome of cardiac cachexia (SOCC) originated from Heymsfield’s observation of the relationship between chronic congestive heart failure and cachexia in 1989, and in 1991 Hisaki Koi et al. called the high degree of nutritional disorders caused by chronic congestive heart failure the cardiac cachexia syndrome.  Malnutrition is an independent risk factor for major surgery, especially for SOCC patients, and it has become a wide consensus among scholars at home and abroad to enhance nutrition before and after surgery and correct hypoproteinemia and anemia based on the importance of cardiac function. John et al. proposed that the conventional diet after SOCC cannot meet the nutritional needs of patients, and there are many complications, the most problematic being pneumonia and respiratory failure, with a mortality rate of 16 Webb et al. proposed that preoperative nutritional support is important for improving cardiac function in patients preparing for direct intracardiac surgery who have significant weight loss with sudden lethal arrhythmias, and can improve the safety of surgery with a significantly higher postoperative survival rate than the control group.  We choose non-whole protein preparation as the main raw material of gastrointestinal nutrition, because most of SOCC patients are treated with acid suppression therapy, and only when pH <;4 can pepsin be activated and participate in digestion and absorption, a large amount of application of whole protein preparation will cause gastrointestinal digestion and malabsorption and a large amount of application of whole protein preparation by bacteria in the large intestine, causing "intestinal failure ". In this regard, we try to extract gastric juice for pH determination before nasal feeding, if pH>;4, the application of acid inhibitors is appropriately reduced, and glutamine is added. In addition, a variety of commercially available gastrointestinal nutrition preparations are often deficient in vitamins and trace elements and should be additionally supplemented when used.  It is very important to keep the gastric tube free of bacterial colonization while nasal feeding of nutrition solution. In our clinical work, we found a high rate of positive bacterial appearance in early morning gastric tube aspirate cultures, and we tried to apply yogurt containing a large amount of active bifidobacteria to close the gastric tube every night with good results.  The traditional view of nutritional support is that gastrointestinal nutrition is usually used in conjunction with parenteral nutrition, but parenteral nutrition should be used with caution in SOCC combined with severe cardiac insufficiency. A large increase in volume during the perioperative period can increase the burden on the heart, and inappropriate parenteral nutrition can cause metabolic disorders of water and electrolytes, sugar and fat, which can affect the prognosis. The treatment of parenteral nutrition for SOCC patients needs to be further explored.  Improper postoperative gastrointestinal nutrition can also cause a series of complications called “feeding edema”, which manifests itself as the opposite of general malnutrition, such as rapid increase in blood volume, hypertension, water and sodium retention, leading to increased cardiac work and aggravating chronic congestive heart failure.  In conclusion, appropriate, aggressive and progressive application of perioperative intragastric nutrition has a positive effect on patients with cardiac cachexia in rheumatic valve disease, reducing perioperative mortality and complication rates and improving long-term quality of life, such as improvement in NYHA cardiac class, weight gain and plasma protein and vitamins.