The skull is an exceptionally hard piece of bone tissue in the body that plays a key role in protecting and supporting the brain as well as the head and facial organs. The skull is too important to be destroyed, but cranial defects are now a common condition that can disrupt the integrity of the cranial cavity and the stability of the intracranial environment, causing much discomfort to the patient’s body. Cranial defects should be taken seriously and it is crucial to go to the hospital for cranial repair as soon as possible. However, in cranial repair surgery, attention should be paid to the choice of repair materials, and good materials will have a better prognosis. Currently, titanium mesh material is widely used in many local hospitals. Compared with the past, the material has its progress, but there are still some problems and shortcomings in clinical practice. What are the adverse effects after skull repair with titanium mesh? After repairing the skull with titanium alloy mesh, some patients may have infection and rejection reactions, and the wear and tear of titanium alloy material on the scalp is more serious, which may lead to the rupture of the patient’s scalp in severe cases, and even the risk of material exposure. In addition, titanium alloy is not very good in forming, and patients are sensitive to hot and cold environment after surgery, which affects postoperative CT examination, and it is also easy to collapse and deform if external force is applied, etc. Titanium mesh may not be well suited for skull repair, but a better material is now available: the new PEEK material. This is a very safe and advanced polymer material with excellent performance. The use of PEEK material for cranial repair surgery can be a good way to avoid some of the adverse effects of the titanium mesh material described above. At present, PEEK material is not yet a common presence in domestic companies to use to develop up, we need to team early introduction of this learning advanced materials, very experienced in these two aspects, team management can not only use PEEK material to carry out surgery, but also continue to improve the improvement of innovative technology, optimize the material engineering design, innovative and creative introduction of the concept of cosmetic plastic surgery, comprehensive carry out PEEK cranioplasty, the postoperative recovery effect is more ideal.