Most of the patients in middle and late stage of lung cancer need to receive chemotherapy, but a small number of patients may not be sensitive or adaptable to chemotherapy, and chemotherapy is not recommended at this time. Most of the patients in the middle and late stages of lung cancer have already metastasized and spread, if the patients still have surgical indications at this time, surgical resection is still the primary treatment, and further chemotherapy can be used after surgery, and the sensitivity of lung cancer to chemotherapy is relatively high, and the effect of chemotherapy is good. Some patients with middle and late stage lung cancer may not be able to undergo surgery due to distant metastasis and spread of the tumor, so they can undergo chemotherapy and other treatments, such as local radiotherapy, targeted therapy, etc., which are often more effective and can control the further development of the disease. However, a small number of patients, such as the elderly and weak, people with serious dysfunction of heart, liver and kidney, and people with malignant disease, cannot tolerate the side effects of chemotherapy, and chemotherapy is not recommended at this time. In addition, chemotherapy is not recommended for patients who are not sensitive to chemotherapeutic drugs and cannot control their conditions, and other treatments such as targeted drugs or immune drugs can be considered according to their conditions. In the middle and late stage of lung cancer, it is still necessary to cooperate with doctors to take active treatment, which can prolong the survival period and improve the quality of life of patients.