The causes of hardness and swelling on both sides of the nose include skin inflammation and systemic sclerosis. 1. Skin inflammation: due to follicular worm infection, mite infection, staphylococcus aureus infection and other conditions, it will lead to skin inflammation, hyperplasia, swelling, hardening, which will be accompanied by the appearance of pimples, pustules, nodules and so on. 2. Systemic sclerosis: an autoimmune connective tissue disease of unknown etiology, involving the skin can be manifested as limited facial skin sclerosis, continued development can lead to skin tautness, shiny, and finally the skin gradually soften. There are other reasons for the swelling on both sides of the nose (e.g. scleroderma, sclerosing mucoedema tessellatum), when you go to the hospital to find out the cause, do not use your own medicine.