Acute liver injury may cause generalized weakness, liver rupture, right upper abdomen discomfort and other symptoms. 1. Generalized fatigue: If patients suffer from acute liver injury, it will lead to the decrease of acetylcholine in the body, the disturbance of sugar metabolism, and the obstacle of fat digestion and absorption in the intestines, etc., which will affect the muscular malnutrition, and the symptom of generalized fatigue will appear. 2. Liver rupture: If the patient suffers from acute liver injury due to sharp object injury, impact or car accident, it may lead to intra-abdominal hemorrhage or extra-abdominal hemorrhage, resulting in liver rupture. 3. Discomfort in the right upper abdomen: If the patient suffers from fatty liver, drug liver or alcoholic liver, it may cause hepatitis and symptoms of acute liver injury. The inflamed area will have radiating pain to the surrounding area, triggering discomfort in the right upper abdomen. If the patient has acute liver injury, he should go to the regular hospital in time, do the relevant examination and actively treat it.