Medicines for nutrition of sciatic nerve include vitamin B12, methylcobalamin, epoprostenol and lipoic acid. 1. Vitamin B12: also known as cobalamin, it needs to be absorbed by the body through endogenous factors secreted by the intestinal tract, and is involved in the transfer of methyl and one-carbon units as well as the synthesis of lipoproteins in the nerve tissues, and has the functions of promoting the development and maturation of erythrocytes and protecting the nerves. It is forbidden for those who are allergic to this drug, and adverse reactions such as skin rash, hypokalemia and hyperuricemia may occur. 2. Methylcobalamin: It is endogenous coenzyme B12, which can promote the utilization of folic acid and nucleic acid metabolism, regeneration of axon of nerve cells, enhancement of transport and conduction function of axon cells, and inhibition of neural cell recession, etc. It is contraindicated in patients with allergy to this drug. It is forbidden for those who are allergic to this drug, and adverse reactions such as loss of appetite, vomiting, diarrhea and nausea may occur. 3. Epalrestat: Improve sensory dysfunction caused by diabetic peripheral neuropathy through reversible and non-competitive inhibition of aldose reductase. It is contraindicated for those who are allergic to this drug, and adverse reactions such as rash, itching, nausea and vomiting may occur. 4. Lipoic acid: belongs to one kind of B vitamins, through blocking protein glycosylation, inhibiting aldose reductase and preventing sorbitol synthesis, treatment of diabetic peripheral neuropathy. It is contraindicated for those who are allergic to this drug, and adverse reactions such as head swelling, dyspnea and sweating may occur. The drug should be used under the guidance of a medical professional according to the condition.