Under normal circumstances, plasma donation is not harmful to the human body, but it should be noted that the interval should be 14 days, plasma donation should not be excessive, and there are no contraindications such as coagulation disorders. Appropriate plasma donation can stimulate bone marrow hematopoiesis, which is conducive to the regeneration of fresh blood, and due to the strong compensatory function of the bone marrow, usually after a short period of time can be restored to the normal blood volume, and will not cause too much impact on the body. Plasma is mainly composed of proteins, various electrolytes, etc. If the interval between plasma donations is too short or the amount of plasma donated is too large, hypoproteinemia and decreased immunity may occur. If there is any coagulation disorder, bleeding reaction may occur after plasma donation, such as bleeding from skin, mucous membranes, nasal cavity, gums and so on. Therefore, plasma donation should be in accordance with national regulations, moderate, appropriate amount of plasma donation, and to ensure that they have no contraindications such as coagulation disorders. After plasma donation, more protein and high iron food should be supplemented to promote plasma resynthesis in the body.