A positive UU in clinical practice is positive for Mycoplasma solani, which refers to the presence of Mycoplasma solani infection in the genital and urinary systems. Male UU positivity is the presence of Mycoplasma urealyticum in male urethral secretion cultures, and transmission is mainly by contact. Male UU positivity may be due to sexual contact, or contact with contaminated objects, such as clothing, seats, towels, etc. Men who have, at the time of contact, their own presence, skin surface ulceration due to inflammation of the urinary system, can be infected with Mycoplasma urealyticum. Some patients are asymptomatic at the initial stage of infection with Mycoplasma urealyticum, but may develop when the internal environment of the body changes and resistance decreases, appearing urgent, frequent and stinging urination, especially when the urine is more concentrated. In addition, Mycoplasma urealyticum can affect sperm activity and can lead to male infertility. Men with Mycoplasma urealyticum infection require comprehensive treatment under the guidance of a physician, and the preferred drugs are macrolides such as azithromycin, doxycycline, and roxithromycin. After 2-3 negative cultures of secretions, one can consider Mycoplasma solani positive or Mycoplasma solani infection to be cured.