Mixed connective tissue disease may cause ear pain symptoms, but ear pain symptoms may also be caused by ear disorders. Mixed connective tissue disease may be due to lesions involving multiple systems and organs, such as skin, muscles, joints, heart, lungs, etc., which simultaneously or not simultaneously show a mixture of manifestations of diseases such as polymyositis, systemic lupus erythematosus, scleroderma, etc. When the lesion involves the skin of the ear and the structure of the ear, the patient may experience otorrheal pain symptoms. In addition to mixed connective tissue diseases, otorrhea may also be caused by diseases of the ear itself, such as otitis media, earwax, ear herpes, ear tumor, ear trauma, etc. Therefore, patients with otorrhea need to improve CT, otoscopy, blood sedimentation, CRP, autoantibodies and other relevant auxiliary examinations to clarify the cause. It is recommended that patients with mixed connective tissue disease who have symptoms of otalgia should go to the Department of Rheumatology and Immunology of regular hospitals, and consult their doctors for related matters.