Thalassaemia, or bead protein-producing disorder anemia, is a severe form of fetus that does not usually have noticeable symptoms in early pregnancy. Pearson’s anemia is an inherited hemolytic disorder that is divided into alpha and beta types. If a pregnant woman is pregnant with a child with severe alpha-pearson’s dysgenerative anemia, there are usually no obvious symptoms in the early stages of pregnancy, and in the middle of pregnancy, the fetus will have symptoms such as dysplasia, generalized edema with ascites, and cardiopulmonary distress, and most often will die of severe hypoxia within a few hours after birth. If a pregnant woman carries a child with severe β-protein generation disorder anemia, the child is usually asymptomatic during pregnancy and at birth, and the disease starts to develop at the age of 3-12 months, with symptoms such as chronic progressive anemia, hepatosplenomegaly, dyspareunia, mental retardation, and disorders of sexual development, and after the age of 1 year, the child develops special features such as enlarged head, high zygomatic cheeks, and sunken nasal bridge. Pregnant women are advised to undergo genetic counseling before marriage, regular obstetric examinations during pregnancy, and timely treatment if their children have the above symptoms.