Cranial defect is a common disease in neurosurgery, which is often caused by craniocerebral trauma due to traffic accidents, production safety accidents, falling objects, falling from height, fights, etc., or left behind after craniotomy for craniocerebral disease due to high cranial pressure and inability to return the bone flap immediately. This kind of cranial defect may occur in various parts of the skull, frontal, temporal, occipital, and top of the skull may occur cranial defect. So after the cranial defect should be timely to the regular hospital to take cranial bone repair surgery, the current use of new polyether ether ether ketone PEEK material for patients with PEEK cranial bone repair plastic surgery. First of all, it is necessary to carry out a detailed scientific diagnostic assessment of the patient, to exclude contraindications to surgery, and three-dimensional CT scanning of the patient’s skull, data collection for three-dimensional reconstruction and the design and production of PEEK materials, according to the patient’s bone window data for accurate personalized customization, through the 3D printing technology to produce PEEK plate can be tightly and accurately embedded in the bone window, to achieve a good reset. After the material is customized and delivered to the hospital, it is sterilized and then the surgery is performed. Generally, an incision is made in the hairline, which does not affect the aesthetics and fully exposes the bone window. The PEEK plate is precisely embedded in the bone window, fixed well, and the layers of tissues are precisely reset, and then the skin is sutured layer by layer to complete the surgery. Polyetheretherketone PEEK material as a cranial bone repair material, and constantly improve and upgrade the technology and optimize the design of the material, and introduce the concept of cosmetic plastic surgery, not only is the cranial bone to restore the integrity of the skull to restore the closure of the cranial cavity to stabilize, but also the factors affecting the appearance of cosmetic plastic surgery treatment, to achieve the anatomical integrity, functional integrity, aesthetic appearance of the organic unity.