Soreness in the knee and calf area is mainly related to inflammation, excessive fatigue, cold or calcium deficiency, and can be relieved by medication, physical therapy or exercise therapy. 1. Medication: When there is a lack of calcium or inflammation in the knee and calf area, it is easy to cause soreness and swelling, you can choose to take calcium gluconate or meloxicam and other drugs for treatment. 2. Physical therapy: long time poor posture, excessive fatigue and coldness in the calf area will easily cause knee and calf soreness, you can choose magnetic heat therapy, combined with intermediate frequency electrical stimulation and other methods of treatment, which will help to alleviate the symptoms of soreness and distension. 3. Exercise therapy: the knee and calf area muscle fatigue is easily triggered by soreness, you can choose to exercise stretching, with local muscle contraction method to relieve, accelerate the absorption of lactic acid, so as to alleviate the symptoms. If the symptoms of knee and calf soreness are more serious, you need to check and evaluate the cause of the disease, under the guidance of the doctor targeted treatment, so as to avoid further aggravation of the symptoms, do not blindly use drugs.